Studies on the Efficacy of Various Antimycotic Drugs on Emerging and Reemerging, Superficial, Cutaneous and Subcutaneous Mycotic Infections
Loading...
Date
2022-05-16
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Pharmaceutical Research International
Abstract
Introduction: The efficacy of five systemic and topical antifungal medications, Voriconazole, clotrimazol, beclometasone, Itraconazole, and Fluconazole, on dermatomycosis, which affects the superficial layers of the skin, nails, foot, and hair, was tested with 180 patients. Methods: Included were specimen collection, processing, microscopy, and culture, as well as antifungal susceptibility testing using the E-test method. The Candida species were confirmed and their susceptibility to Voriconazole and Fluconazole was tested using the automated Vitek 2. Results: The final strain identification indicated 41 dermatophytes (69.49%), 11 non-dermatophytic molds (NDM) (18.64%), and 7 yeasts (11.87%). (candida). Candida was the most prevalent nondermatophyte species found. Trichophyton rubrum was the most prevalent species isolated in Tinea corporis, T. cruris, T. capitis, and T. faciei. When tested with the E strips, all dermatophyte strains showed the greatest vulnerability to beclometasone and clotrimazole (MIC range of 0.04 0.64), but homogeneous resistance to Fluconazole (i.e. MIC 32 g/ml). Conclusion: Variation in species distribution was shown to be statistically significant (p = 0.001) in terms of clinical presentation.
Description
Keywords
Dermatomycosis, antifungal Etest, VITEK-2 vericonazole itraconazole, clomatrizole, beclometasone, and Fluconazole
Citation
C. M. Ezenwa, C. N. Obum-Nnadi, Dennis Amaechi, V. N. Unegbu and K. S. Nwokorie(2022). Studies on the Efficacy of Various Antimycotic Drugs on Emerging and Reemerging, Superficial, Cutaneous and Subcutaneous Mycotic Infections. Journal of Pharmaceutical Research International 34(38A): 46-50, 2022; Article no.JPRI.86693 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759)