Phytochemicals and Anticancer Activity of Methanol Extract of Trigonella foenum-greacum Seed on Breast Cancer Cell Lines
| dc.contributor.author | Aransiola, Sesan Abiodun | |
| dc.date.accessioned | 2025-01-13T21:16:36Z | |
| dc.date.available | 2025-01-13T21:16:36Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | This study was aimed to examine the anticancer potential of Trigonella foenum-greacum seed methanol extract by analyzing its phytochemicals and its breast cancer cells effects. The anti-cancer efficacy of the extract was tested on fibroblast cells and MCF-7 through various cellular assays, including apoptosis, mitochondrial membrane potential, reactive oxygen species, cell cycle distribution, and cell cytotoxicity assay were all investigated. By using GC-MS analysis, fifty-five bioactive compounds were identified in the extract. When the cancer cell lines were treated with the extract, the typical apoptotic morphology was observed, this resulted in a dose-dependent reduction of cancer cell migration and adhesion. Flow cytometry studies revealed that the extract significantly induced apoptosis by triggering a change from G2/M to polyploidy (>G) at greater doses. Furthermore, the extract increased mitochondrial depolarization and ROS levels. This study demonstrates the extract's anti-cancer properties and highlights the need for further analysis to understand how Trigonella foenum-greacum seed extract induces program cell death through multiple signaling pathways at varying concentrations. | |
| dc.identifier.uri | https://doi.org/10.1016/j.sajb.2023.07.021 | |
| dc.identifier.uri | https://repository.uniabuja.edu.ng/handle/123456789/673 | |
| dc.language.iso | en | |
| dc.publisher | South African Journal of Botany | |
| dc.title | Phytochemicals and Anticancer Activity of Methanol Extract of Trigonella foenum-greacum Seed on Breast Cancer Cell Lines | |
| dc.type | Article |