Chitosan-Based Nanoparticles to Bypass the Blood-Brain Barrier for the Treatment of Neurological Diseases: A Review
| dc.contributor.author | Aransiola, S.A. | |
| dc.date.accessioned | 2025-03-24T12:01:35Z | |
| dc.date.available | 2025-03-24T12:01:35Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Neurological disorders are increasing exponentially and at an alarming rate, affecting great number of people globally. Normal functioning of the central nervous system (CNS) depends on the blood-brain barrier's (BBB) integrity. Therapeutic amount of some drugs cannot reach the brain; therefore majority of effective pharmaceuticals that have been produced for the treatment of neurological illnesses have subpar therapeutic results. Due to lack of targeted drug delivery mechanism, there is a large concentration of these drugs in the body's essential organs, and this might be harmful to the body. To surmount this challenge, patients are given high doses of medication in an effort to reach the brain more quickly, which ultimately causes off-target organ toxicity. Therefore, there is a pressing need to develop effective treatments for neurological disorders. Nano systems for drug delivery have been investigated because of their targeting capabilities. Chitosan is a natural polymer that is frequently used to create drug delivery nano-systems. Because of its special qualities, including biocompatibility, biodegradability, and mucoadhesive properties, it enables targeted therapy without posing any hazardous risks. Recently, drug delivery nano-systems, hydrogels, and scaffolds made of chitosan have been employed to treat several neurological conditions. This review will concentrate on brain-targeting nanoparticles made of chitosan. | |
| dc.identifier.citation | Asuku1, A.O; Ayinla, M.T; Aransiola1, S.A; Ajibare, A.J; Adeyemo, M.B;Adeyemo, R.O .; 2024. Chitosan-Based Nanoparticles to Bypass the Blood-Brain Barrier for the Treatment of Neurological Diseases: A Review. Pacific Journal of Medical Sciences, 25, (1), pp.45-65 | |
| dc.identifier.uri | https://www.pacjmedsci1625.com/_files/ugd/1c6c79_0a58e70b2ab24c09b1f26acbde77a491.pdf | |
| dc.identifier.uri | https://repository.uniabuja.edu.ng/handle/123456789/742 | |
| dc.language.iso | en | |
| dc.publisher | Pacific Journal of Medical Sciences, | |
| dc.subject | Chitosan | |
| dc.subject | neurological disorders | |
| dc.subject | blood brain barrier | |
| dc.subject | nanoparticles | |
| dc.subject | drugs | |
| dc.title | Chitosan-Based Nanoparticles to Bypass the Blood-Brain Barrier for the Treatment of Neurological Diseases: A Review | |
| dc.type | Article |